Age-related diseases and cancer
Age-related diseases
COENZYME I
1
CONTENTS
A. NAD biosynthetic pathways and metabolism
B. NAD consuming enzymes in health and disease
C. Age-related diseases and cancer
D. Mechanisms of NAD Precursors in humans and animal models
E. NAD and the hallmarks of aging
2
A.
NAD biosynthetic pathways and metabolism
3
NAD biosynthetic pathways and metabolism
Eric Verdin. (2015). Special Section 350(6265): 1208-1213.
NAD biosynthetic pathways and metabolism in different cellular compartments.
4
B.
NAD consuming enzymes in health and disease
5
NAD consuming enzymes in health and disease
E F. Fang,. (2017). NAD+: a key metabolic regulator with great therapeutic potential: 1120-1143.
NAD availability can influence the activity of three groups of master regulator enzymes
the sirtuins, the PARPs and cyclic ADP-ribose synthases. Each group of enzymes regulate many biological processes and can thus couple changes in NAD levels with a wide range of physiological responses.
6
C.
Age-related diseases and cancer
7
1980s
1930s
……
Age-related diseases and cancer could be the consequence of a decline in NAD+ concentrations
Amanda Garrido (2017). Trend in cancer 181: 181-199.
Age-related diseases and cancer
Metabolic syndrome including cardiovascular disorders, type 2 diabetes and obesity, Neurodegenerative diseases such as Alzheimer and Parkinsondiseases, arthritis, and osteoporosis, and cancer are some of the diseases that
commonly affect human health during aging.
8
D.
Benefits and mechanisms of NAD precursors in humans and animal models
9
Benefits and mechanisms of NAD precursors in humans and animal models
GSultani. (2017). Trends in Molecular Medicine23(10): 900-918
10
辅酶一NAD与老年化疾病ppt课件 来自beplayapp体育下载www.apt-nc.com转载请标明出处.