辅酶一(nad)与老年化疾病.ppt

Age-related diseases and cancer
Age-related diseases
COENZYME I
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CONTENTS
A. NAD biosynthetic pathways and metabolism
B. NAD consuming enzymes in health and disease
C. Age-related diseases and cancer
D. Mechanisms of NAD Precursors in humans and animal models
E. NAD and the hallmarks of aging
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A.
NAD biosynthetic pathways and metabolism
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NAD biosynthetic pathways and metabolism
Eric Verdin. (2015). Special Section 350（6265）: 1208-1213.
NAD biosynthetic pathways and metabolism in different cellular compartments.
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B.
NAD consuming enzymes in health and disease
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NAD consuming enzymes in health and disease
E F. Fang,. (2017). NAD+: a key metabolic regulator with great therapeutic potential: 1120-1143.
NAD availability can influence the activity of three groups of master regulator enzymes
the sirtuins, the PARPs and cyclic ADP-ribose synthases. Each group of enzymes regulate many biological processes and can thus couple changes in NAD levels with a wide range of physiological responses.
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C.
Age-related diseases and cancer
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1980s
1930s
……
Age-related diseases and cancer could be the consequence of a decline in NAD+ concentrations
Amanda Garrido (2017). Trend in cancer 181: 181-199.
Age-related diseases and cancer
Metabolic syndrome including cardiovascular disorders, type 2 diabetes and obesity, Neurodegenerative diseases such as Alzheimer and Parkinsondiseases, arthritis, and osteoporosis, and cancer are some of the diseases that
commonly affect human health during aging.
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D.
Benefits and mechanisms of NAD precursors in humans and animal models
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Benefits and mechanisms of NAD precursors in humans and animal models
GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918
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