明胶基温敏性聚n异丙基丙烯酰胺NIPAAm水凝胶制备及其在药物缓释中应用.pdf

高了水凝胶的温敏性、响应速率和对药物的载药释药性能。:70,N-。.***尿嘧啶的包封率分别大于82%和90%,均具有良好的包埋效果及缓释效果。,水凝胶对BSA的包封率有所降低,但对5.***尿嘧啶的包封率无明显影响。,但对5.***尿嘧啶的释放没有明显影响。,在37℃。关键词:明胶,Ⅳ-异丙基丙烯酰***,水凝胶,温敏性,缓释性万方数据THEPREPARATIONOFPOLY(N-ISOPROPYLACRYLAMIDE)(LCST)similar埘mbodytemperature,poly(N-isopmpylacrylamide)(PNIPAAm)-maleylgelatin(N—MAGEL)WaSpreparedbyacylationreactionbetweengelatinandmaleicanhydride(/via)·MAGEL—CO-PNIPAAmhydrogelwerepreparedbyfreeradicalpolymerizationwithN-’Smore,N-MAGEL-CO-PNIPAAmhydrogelcrosslinked、ⅣimBis-acrylamide(N—MAGEL—Bis—PNIPAAm)-MAGEL/NIPAAmweightingratiosonthebiology—chemicalcharacteristics(thermo—responsivebehaviors,watercontentsanddrugreleaseefficiencyeta1)--∞回ofN—MAGELreachedmaximum(96%)—MAGEL/NIPAAmrangedfrom40:60to60:40,thepreparedN-·MAGEL-·CO—-%percentageofN-MAGELhaShighest万方数据equilibriumswellingratioindeionizedwaterat25℃.eslowlyasaddingN—MAGELinN—MAGEL—CO-—MAGEL—CO-PNIPAAmhydrogelhadgoodencapsulationefficiency(98%)andcontrolledreleaseforbovineserumalbumin(BSA)and5-