胃黏膜损伤相关疾病中药的研究现状及其开发思路.pdf

- 302 - Drug Evaluation Research August 2010
胃黏膜损伤相关疾病中药的研究现状及其开发思路
许海玉 1, 2,赵平 1, 2,张铁军 2 *,刘昌孝 3,许浚 2
1 天津中医药大学,天津 300193;
2 天津药物研究院中药现代研究部,天津市中药质量控制技术工程实验室,天津 300193;
3 天津药物研究院释药技术与药代动力学国家重点实验室,天津 300193
摘要胃黏膜损伤相关疾病都是一些常见病、多发病,属中医“胃痞”、“胃脘痛”的范畴。为了发挥中医药在治疗胃黏膜
损伤相关疾病的作用,提高研发水平,从流行病学、发病机制、药物干预途径和治疗胃黏膜损伤相关疾病的中药新
药开发思路 4 个方面进行综述。
关键词胃黏膜损伤相关疾病;中药;新药开发
中图分类号:R573 R975 文献标志码:A 文章编号:1674–6376(2010)04–0302–05
Research status and development thoughts of gastric mucosal injury
and related diseases treated with Chinese materia medicine
XU Hai-yu1,2, ZHAO Ping1,2, ZHANG Tie-jun2, LIU Chang-xiao3, XU Jun2
1 Tianjin University of Traditional Chinese Medicine,Tianjin 300193, China;
2 Tianjin Engineering Laboratory of Quality Control Techniques for TCM, Tianjin Institute of Pharmaceutical Research, Tianjin
300193, China;
3 State Key Laboratory of Drug Delivery Technology and ics, Tianjin Institute of Pharmaceutical Research, Tianjin
300193, China
Abstract The gastric mucosal injury and related diseases that called stomach flatulence or epigastralgia in traditional Chinese
medicine mon and frequent diseases. To make the traditional Chinese medicine play its role in the treatment of
gastric mucosal injury and related diseases, and to improve the level of research, four aspects including epidemiology,
pathogenesis, the approach of drug int