2015chapter11-1激素药物.pptx

第十一章激素类药物Hormone drugs
Hormones
Natural Hormones are endogenous(内源的)pounds in human.
Hormone drugs are mainly used to heal the diseases which are caused by endocrine(内分泌)disturbance.
“Hormone” is a kind of chemical messenger secreted by endocrine epithelia(内分泌腺上皮细胞), which enters into blood or lymph fluid(淋巴液)and reach special locations or ans in vivo.
Adjustment of Hormone Secretion
Hormone secretion is doubly adjusted by nerves-endocrine system(神经-内分泌双系统).
Hypothalamus(下丘脑)secrete hormones promoting trophic hormone (促激素释放激素).
Anterior pituitary(腺垂体) secrete “trophic hormone(促激素)”
an accept hormone.
Adjusted by the long and short feedback(反馈) mechanisms.
激素的分泌和双重调节
过多:巨人症
过少:侏儒症
过多:低血糖
过少:糖尿病
激素的影响
过多:心悸、多汗
过少:肥胖、嗜睡
生长激素
胰岛素
甲状腺素
前列腺素类药物
甾体激素类药物
肽类激素类药物
前列腺素
类药物
肽类激素
类药物
甾体激素
激素类药物
米索前列醇
降钙素
雌二醇
己烯雌酚
地塞米松
第一节前列腺素类药物
prostaglandin drugs
Basic chemical Structure
This acid contains 20 carbon atoms.
7 carbons and carboxyl group in the upside chain
8 carbons in the downside chain
五元脂环
常见的前列腺素类化合物