the management of non-insulin-dependent diabetes during pregnancy开题资料.pdf

Diabetes Research and Chmcal Practice, I (1986) 281-287
Elsevier 281
DRC 00043
The management of non-insulin-dependent diabetes during
pregnancy
Edward J. Coetzee 1'* and . Jackson 2
Departments of t Obstetrics and Gynaecology. and 2Medicine, Medical School, University of Cape Town, Anzto Road, Observato O, 7925,
and Groote Schuur Hospital. Repubhc o[" South Afrtca
(Received 12 March 1985. accepted 19 September 1985)
Key words: Non-insulin dependent diabetes; Pregnancy: Oral hypoglycemics; Perinatal mortality and morbidity
Summary
We propose a rational regimen for management of non-insulin-dependent pregnant diabetics (NIDD), using
appropriately constituted calorie-restricted diets with the oral agents metformin and glibenclamide as may
be necessary, with rapid recourse to insulin if the latter do not produce excellent control of blood glucose.
Using this regimen between June 1974 and December 1983 we have managed 423 new diabetics (ND, di-
agnosed during pregnancy) with a perinatal mortality (PNM) of 14 per 1000 and 268 established diabetics
(known diabetics, KD) with a PNM of